Registration Dossier
Registration Dossier
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Reaction mass of N-(4-(bis(4-(methylamino)phenyl)methylene)cyclohexa-2,5-dienylidene)-N-methylmethanaminium acetate and [4-[[4-(dimethylamino)phenyl][4-(methylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium acetate and [4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]dimethylammonium acetate
EC number: 944-191-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
One study performed on analogue substance 2 (BASF, 2010) following OECD 429 shows that the substance is a skin sensitizer.
Based on the read across considerations the same results aplly to Basic Violet 1 Acetate that is considered to be a skin sensitizer.
Migrated from Short description of key information:
Analogue substance, LLNA, sensitizing
Justification for selection of skin sensitisation endpoint:
GLP and guideline compliant study.
Justification for classification or non-classification
According to CLP Regulation, For Category 1, a stimulation index of three or more is considered a positive response in the local lymph node assay. The substance shows a SI >3. Moreover, following Table 3.4.3 the EC3<2% for the LLNA test,which corresponds to a classification of Category 1A H317: May cause an allergic skin reaction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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