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EC number: 700-208-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-04-27 - 2007-06-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an internationally accepted guideline. All study parameters are based on the specific guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide AND N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide
- EC Number:
- 700-208-8
- Molecular formula:
- C7H11N3O
- IUPAC Name:
- Reaction mass of N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide AND N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide
- Test material form:
- solid: crystalline
- Details on test material:
- Chemical name: N-(3(5)-Methyl-1 H-pyrazol-1 -yl-methyl)-acetamid
Code of the sponsor: P 70/05 Formula: C7H11N3O
Description: white, amorphous solid
Purity: > 99 % (HPLC and NMR)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The study room and cages were cleaned and disinfected before the animals arrived. During the study, the room and cages were cleaned at regular intervals. From the randomisation until sacrificing a single animal was housed in a Makrolon® Type 3 cage.
ALTROMIN 1324, pelleted standard diet (ALTROMIN, D-32791 Lage/Lippe) Batch: 161007/1025
With the exception of overnight fasting before oral administration and until 3 hours after administration food was available ad libitum.
Environment: air conditioned,
temperature: 22 - 25 °C,
relative humidity: 33 - 70 %, with a shortly rising on 75 %
artificial light was set to give a cycle of 12 hours light and 12 hours dark; the light phase was from 6.30 a.m. - 6.30 p.m.
The diet is delivered periodically with an accompanying certificate of analysis giving details of nutritional composition and levels of specified contaminants (heavy metals, aflatoxins and pesticides).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tylose MH 1000 in deionised water
- Details on oral exposure:
- Route of administration: orally, by gavage; using a metal catheter and disposable plastic syringes.
Rationale: The acute toxicity is to determine at first by the oral administration. - Doses:
- 2000 mg/kg body weight (b.w.)
- No. of animals per sex per dose:
- 6 female animals
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the course of investigation.
- Clinical signs:
- other: Only on the day of administration some clinical signs (squatting position, rough hair coat, impaired general condition) were observed in the animals of the second step of the study (animals 4 - 6).
- Gross pathology:
- No substance dependent pathological finding was observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity of N-(3(5)-Methyl-lH-pyrazol-l-yl-methyI)-acetamid (P 70/05) was tested in 6 female Charles River Wistar rats according toOECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).
The test item was administered at the single dose of2000mg/kg body weight (Limit test) by gavage.
All animals were examined for mortality, clinical signs and body weight gain. The pathological alterations of organs were examined at the end of a 14-day observation period.
None of the animals died after a single oral administration of 2000 mg/kg b.w. N-(3(5)-Methyl-1 H-pyrazol-1 -yl-methyl)~acetamid (P 70/05).
The LD50 p.o. rat is > 2000 mg/kg b.w.
Apart from some clinical signs on the day of administration which are signs of an impaired general condition no clinical symptoms were observed during the further course of investigation.
The body weight gain of the animals was not affected. No substance dependent pathological finding was observed. - Executive summary:
The acute oral toxicity of N-(3(5)-Methyl-lH-pyrazol-l-yl-methyI)-acetamid (P 70/05) was tested in 6 female Charles River Wistar rats according toOECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).
The test item was administered at the single dose of2000mg/kg body weight (Limit test) by gavage.
All animals were examined for mortality, clinical signs and body weight gain. The pathological alterations of organs were examined at the end of a 14-day observation period.
None of the animals died after a single oral administration of 2000 mg/kg b.w. N-(3(5)-Methyl-1 H-pyrazol-1 -yl-methyl)-acetamid (P 70/05).
The LD50 p.o. rat is > 2000 mg/kg b.w.
Apart from some clinical signs on the day of administration which are signs of an impaired general condition no clinical symptoms were observed during the further course of investigation.
The body weight gain of the animals was not affected. No substance dependent pathological finding was observed.
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