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EC number: 267-007-0
CAS number: 67762-26-9
This substance is identified by SDA Substance Name: C14-C18 and C16-C18 unsaturated alkyl carboxylic acid methyl ester and SDA Reporting Number: 04-010-00.
To test for possible anticlastogenic
effects of fatty acids, the methyl esters of fatty acids — short-chain
to long-chain — were examined on busulfan in Chinese hamster bone-marrow
cells using the chromosome aberration test. When the experimental
animals were treated with fatty acid esters and the mutagen, the
chromosome-breaking actions of busulfan were not modulated by the
short-chain fatty acids, but the fatty acids from lauric acid (C12)
up to nonadecanoic acid (C19) reduced the rate of aberrant
metaphases from 9.4 to about 3% at doses of 100 mg/kg and less. Other
chemical properties of the fatty acids (saturated or not, number of
double bonds, even- or odd-numbered) had no influence on the
anticlastogenic effects. The only exceptions to this rule were
arachidonic acid, which had no effect, and γ-linolenic acid, which had
no consistent effect on the action of busulfan
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