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EC number: 252-161-3
CAS number: 34708-08-2
controls were assessed at the laboratory at least twice a year. During
2011 (prior to this experiment), the result from the positive control
study had resulted in allergic contact dermatitis in >15% of the test
animals when testing alpha-hexylcinnamaldehyde as a skin sensitiser.
Alpha-hexylcinnamaldehyde is recommended to use by the Commission
Regulation (EC) No 440/2008, B.6 and OECD 406 since it causes moderate
skin sensitisation in guinea pigs. No further details are provided.
of First Challenge:
animals of control group 1 and 18 of 20 animals of the test group did
not show any skin reactions after the first challenge with 15%
(weight/weight) test item in diglyme. Two animals of the test group
(animals no.16 and no. 19) showed discrete or patchy erythema at the
48-hour reading after the first challenge with 15% test item in diglyme.
One animal of control group 1 (animal no.12) and one animal of the test
group (animal no. 19) showed discrete or patchy erythema at the 48-hour
reading after the first challenge with 5% test item in diglyme and
another animal of the test group (animal no. 32) showed discrete or
patchy erythema at the 24-hour as well as at 48-hour reading after the
first challenge with 5% test item in diglyme.
of Second Challenge:
animal (animal no. 19) of the test group showed discrete or patchy
erythema at the 48-hour reading
after the challenge with 15% (weight/weight) test item in diglyme and
one animal of the test
group (animal no. 14) showed discrete or patchy erythema at the 24-hour
reading after the challenge
with 5% (weight/weight) test item in diglyme. No skin reactions occurred
in the control groups.
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