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EC number: 252-161-3 | CAS number: 34708-08-2
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
OECD TG 211 test proposal
Key value for chemical safety assessment
Additional information
There are no data available with the registered substance triethoxy(3-thiocyanatopropyl)silane CAS 34708-08-2. Therefore a long-term toxicity to aquatic invertebrates study OECD TG 211 is proposed.
A long-term toxicity to invertebrates study is proposed because the short-term aquatic invertebrate data determined a 24 hour EC50 value of 29 mg/L, which represents a similar magnitude of short-term toxicity obtained with the fish study, where an LC50 value in the range 10 to 18 mg/L was determined. Therefore, taking into consideration animal welfare and the objective to reduce testing with vertebrates, it is proposed to conduct a long-term aquatic toxicity study with invertebrates rather than with fish. It is additionally proposed to conduct a Dose Range Finding (DRF) study during the OECD TG 211, the results of which will be compared with the available short-term toxicity to invertebrates study to determine the most appropriate concentration range, and with the short-term toxicity to fish study to confirm the most sensitive trophic level.
In the meantime, a PNEC has been derived for the purpose of chemical safety assessment using the lowest EC/LC50 value in the short-term aquatic toxicity studies, which in this case is a conservative 96 hour 10 mg/l with fish. An assessment factor of 1000 was applied to derive the freshwater PNEC using the short-term fish result.
Details on how the PNEC and the risk characterisation ratios have been derived can be found in IUCLID Section 6.0 and Chapters 9 and 10 of the Chemical Safety Report, respectively.
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