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EC number: 252-161-3
CAS number: 34708-08-2
key study for the skin irritation of
triethoxy(3-thiocyanatopropyl)silane (CAS No. 34708-08-2, EC No.
252-161-3) found very slight irritant effects to the skin of rabbit,
below the EU threshold for classification (Asta-Werke AG, 1987a,
reliability score 2). The study was conducted according to OECD Test
Guideline 404 but not in compliance with GLP.
key eye irritation study was conducted according to OECD Test Guideline
405 but not in compliance with GLP and found the test material to be a
non-irritant when applied undiluted to the eyes of rabbits (Asta-Werke
AG, 1987b, reliability score 2).
key skin irritation study was conducted according to OECD Test Guideline
404 but not in compliance with GLP (Asta-Werke AG, 1987a, reliability
score 2). The test material (0.5 mL) was noted to be slightly irritating
to male rabbit skin following occlusive application for 4 hours. For the
three rabbits, mean individual 24/48/72-hour erythema scores were 1-1.3
(fully reversible within 6 days), with corresponding mean oedema scores
of 0 (either no individual findings or fully reversible within 48
hours). There were no signs of systemic toxicity, or mortality
throughout the study.
key study for eye irritation of triethoxy(3-thiocyanatopropyl)silane was
conducted according to OECD Test Guideline 405 but not in compliance
with GLP (Asta-Werke AG, 1987b, reliability score 2). The test substance
was non-irritating when 0.1 mL was applied undiluted to the eyes of
rabbits (one male, two females), with observations up to 72 hours. The
mean individual 24/48/72-hour scores were 0 for the cornea, iris, and
chemosis (all individual timepoint scores at 24-72 hours were 0). For
conjunctival redness, the mean individual 24/48/72-hour scores were
0-0.66, and fully resolved in the two affected animals within 48 hours.
There were no overt signs of systemic toxicity or mortality throughout
the course of the study.
is no indication of corrosivity in any of the available studies.
Based on the available information, no classification is required for
skin or eye irritation in accordance with Regulation (EC) No. 1272/2008.
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