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EC number: 252-161-3
CAS number: 34708-08-2
Reliable short-term toxicity test
results are available for the registered substance,
triethoxy(3-thiocyanatopropyl)silane (CAS 34708-08-2; EC No. 252-161-3),
for freshwater fish (Danio rerio, reported as Brachydanio rerio),
invertebrates (Daphnia magna) and algae (Desmodesmus
subspicatus, reported as Scenedesmus subspicatus). The
relevant short-term values are:
Fish: LC50 (96 h):
between 10 and 18 mg/l (nominal), expressed in terms of the
concentration of the parent substance;
Invertebrate: EC50 (24
h): 29 mg/l (nominal), expressed in terms of the concentration of the
Algae: ErC50 (96
h): 160 mg/l; NOErC: 32 mg/l (nominal), expressed in terms of
the concentration of the parent substance.
Reliable long-term toxicity test
results are not currently available, however there are ongoing studies
for the long-term fish and aquatic invertebrates endpoints, conducted
according to OECD TG 210 and 211, respectively, and in accordance with
GLP. The PNECaquatic will be updated once the results of these studies
An activated sludge
respiration inhibition 3-hour EC50 value of 130 mg/l and an EC10
value of 4.2 mg/l (loading rate, nominal) were determined in a reliable
study. It was not possible to determine a NOEC value in the study (NOEC
was <1.0 mg/l (loading rate, nominal)).
The registered substance is
susceptible to hydrolysis reactions, as described in Section 5.1.2 of
IUCLID. Therefore it is likely that, in the available aquatic studies,
the test organisms were exposed to a mixture of the hydrolysis products
of the substance and the test substance. A functional group
associated with ecotoxicity by a specific mode of action (thiocyanate)
is present in both the registration substance and the silanol hydrolysis
product, and the effects seen are attributed to this. It is therefore
reasonable to conclude that both the parent and hydrolysis product could
contribute to any effects observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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