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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study lacks some details; in this study an 80% solution was tested
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Skin irritation was evaluated following application of a 80% aqueous solution
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-)
EC Number:
237-864-5
EC Name:
Disodium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-)
Cas Number:
14025-15-1
Molecular formula:
C10H12CuN2O8.2Na
IUPAC Name:
Copper(2+) ion disodium 2-({2-[bis(carboxylatomethyl)amino]ethyl} (carboxylatomethyl)amino)acetate
Test material form:
solid - liquid: suspension
Details on test material:
Name: Cutrilon (copper complex of Trilon B)
Appearance: solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No details available.

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
No info
Duration of treatment / exposure:
The backs of the animals were treated for 1, 5, 15 min or20 h.
The ears of the animals were treated for 20 h.
Observation period:
8 days
Number of animals:
not indicated

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: see below
Irritant / corrosive response data:
Effects on the back after 24 h: no abnormalities observed following exposure for 1, 5 or 15 min. Slight red staining observed following 20 h of exposure.
Effects on the back after 8 days: no abnormalities observed.

Effects on the ear after 24 h: slight redness observed following exposure for 20 h
Effects on the ear after 8 days: no abnormalities observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Although slight irritation (redness) was observed, no classification and labeling was considered to be needed based on the results of this study.