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EC number: 237-864-5
CAS number: 14025-15-1
The study was carried out based on the
guidelines described in:
- OECD No.402 (1987) "Acute Dermal Toxicity"
- Commission Regulation (EC) No 440/2008,
B3: "Acute Toxicity (Dermal)"
- EPA, OPPTS 870.1200 (1998), "Acute Dermal
- JMAFF Guidelines (2000), including the
most recent revisions.
administered to five Wistar rats of each sex by a single dermal
occlusive application at 2000 mg/kg body weight for 24 hours. Animals
were subjected to daily observations and weekly determination of body
weight. Macroscopic examination was performed after terminal sacrifice
(Day 15). No mortality occurred. Chromodacryorrhoea was noted in two
males and one female on Day 1 or 2. In single females hunched posture
(Day 1) or piloerection (Day 6) were noted. Scabs were seen in the
treated skin-area of one male and three females during the observation
period. Body weight gain in males and females was within the range
expected for rats of this strain and age used in this type of study. No
abnormalities were found at macroscopic post mortem examination of the
animals. The dermal LD50 value of EDTA-Fe(NH4)NH4OH
in Wistar rats was established to exceed 2000 mg/kg body weight.
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