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EC number: 237-864-5
CAS number: 14025-15-1
Two studies were available on skin
irritation, one using a 80% solution, the other study using a 50%
solution. The 80% solution showed slight skin irritation but not
sufficient for classification, the 50% solution did not show skin
irritation. Two studies were also available for eye irritation. The key
study showed irritation just sufficient to require classification, the
supporting study showed slight irritation not sufficient for
Days after application
Mean score iritis
Mean score redness Days 1/2/3
Mean score chemosis Days 1/2/3
Mean all anim.
PC = pupil
contracted, DC= detachment of the cornea, S = suppuration
Most metal chelates are not irritating to
the skin (see read across document in section 13). Most metal chelates
are neither irritating to the eyes, but in this case EDTA-CuNa2 was
borderline irritating to the eyes.
Based on the results of two skin irritation
studies it was concluded that no classification was needed for this
endpoint. For the endpoint eye irritation classification with GHS Cat. 2
(2A) should be applied based on the borderline eye irritation observed.
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