Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very limited reported study
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Examination of acute oral toxicity in mice after ip administration
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name: Cutrilon (copper complex of Trilon B)
Appearance: solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
not indicated
No. of animals per sex per dose:
not indicated
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 200 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Clinical signs consisted of: dyspnoea, spasms, staggering gait, apathy, tearing, and animals were laying down.

At necropsy the animals did not show presence of substance accumulation.

Applicant's summary and conclusion

Conclusions:
The acute LD50 value via ip administration in mice is ca. 200 mg/kg bw.