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EC number: 266-587-2
CAS number: 67151-63-7
Estimation of pKa of Jeffcat ZR50:
The point of inflection of the reaction of Jeffcat ZR50 with the titrant
was determined from the ratio of change in pH of the solution to change
in volume after each addition of the acid; versus mean volume of the
acid applied. From the point of inflection curve, two points at 30 mL
and 48 mL were obtained as volumes of the titrant consumed.
The volumes were divided by 2 to obtain the mid-point of the
The mid-point of the point of the neutralisation points was therefore
obtained at the stage of the titration when 15mL and 24 mL of the
titrant had been added to the test solution. The pKa of Jeffcat ZR50 was
estimated as 9.54 (the pH when 16 mL of titrant had been added to test
solution) and 8.88 (i.e. pH at addition of 24 mL of titrant).
In the formal determination, performed comparable to the estimation
phase, the pKa of Jeffcat ZR 50 was determined as 9.6± 0.5 and 8.9±0.5.
The dissociation constants of the test substance were determined to be 9.6 and 8.9 at ambient temperature following a GLP-compliant study conducted in accordance with guideline OECD 112 using the titration method (Younis S, 2012).
pKa1: 9.6 at 20°C
pKa2: 8.9 at 20°C
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