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EC number: 266-587-2 | CAS number: 67151-63-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR prediction using the most recent version of ECOSAR (2011) - can be used as key information in a weight-of-evidence approach.
- Justification for type of information:
- 1. SOFTWARE
On-Line EPI Suite™ User's Guide (v4.00 - v4.11).
2. MODEL (incl. version number)
ECOSAR v.1.11.
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CC(CN(CCCN(C)C)CCCN(C)C)O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- The ECOSAR model and underlying methodology has been presented in a document developed over a period of more than 25 years by EPA/OPPT, EPA contractors, and/or others in the scientific and technical community to screen chemicals in the absence of data: Methodology document for the Ecological Structure-Activity Relationship Model (ECOSAR) Class Program estimating toxicity of industrial chemicals to aquatic organisms using the Ecosar (ecological structure actiivity relationship) class program. MS-Windows Version 1.11. May 2012.
5. APPLICABILITY DOMAIN
See Methodology document for the Ecological Structure-Activity Relationship Model (ECOSAR) Class Program and Interpretation QSAR Class Reference Documents available in the On-Line ECOSAR Help section of ECOSAR.
6. ADEQUACY OF THE RESULT
see QPRF
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- The ECOSAR (ECOlogical Structure Activity Relationships) class program for microsoft windows v1.11; within Estimation Programs Interface for Microsoft Windows, EPI Suite version 4.11
- Author:
- US EPA
- Year:
- 2 011
- Bibliographic source:
- Software package: ECOSAR v1.11, U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, 1200 Pennsylvania Ave., N.W. Washington, DC 20460-0001, USA.
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR v.1.11
- Version / remarks:
- Guidance on information requirements and chemical safety assessment
Chapter R.6: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- QSAR predictions were conducted using ECOSAR v.1.11 (2011) using the QSARs for aliphatic amines and neutral organics
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[bis[3-(dimethylamino)propyl]amino]propan-2-ol
- EC Number:
- 266-587-2
- EC Name:
- 1-[bis[3-(dimethylamino)propyl]amino]propan-2-ol
- Cas Number:
- 67151-63-7
- Molecular formula:
- C13H31N3O
- IUPAC Name:
- 1-Bis(3-(dimethylamino)propylamino)-2-propanol
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- other: Daphnid
- Details on test organisms:
- Daphnid (not specified)
Results and discussion
Effect concentrations
- Duration:
- 21 d
- Dose descriptor:
- other: ChV
- Effect conc.:
- 7.2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- other: Predicted value
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- QSAR predictions were conducted using the latest version of US EPA's ECOSAR (v.1.11, 2011) using input values of -0.14 for log Kow and 3.37E+005 mg/L for water solubility in the QSAR for aliphatic amines. The model predicted a chronic value for daphnid of 7.2 mg/L. Because the substance falls within the applicability domain of the models these predicted values can be considered reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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