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EC number: 266-587-2
CAS number: 67151-63-7
After the intradermal induction well-defined erythema and slight edema
were observed at the injection sites of the control group animals and
test group animals at which only Freund's adjuvant/0.9% aqueous
NaCl-solution (1:1) was applied. Injection of the test substance in 0.9%
aqueous NaCl-solution caused well-defined erythema and very slight edema
in the animals of the test group. After application of the test
substance preparation in Freund's adjuvant/0.9% aqueous NaCl-solution
(1:1) well-defined erythema and slight edema could be observed in the
test group animals.
The control group animals which were treated with 0.9% aqueous
NaCl-solution did not show any skin reactions.
The percutaneous induction was only carried out in the test group
because with aqua bidest. a vehicle was used, that was not expected to
influence the result of the study.
Incrustation, partially open (caused by the intradermal induction) in
addition to well-defined erythema and slight edema could be observed.
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