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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, essential details given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
unchanged solidified test substance
Duration of treatment / exposure:
single exposure
Observation period:
24 h, 8 days
Number of animals:
2
Details on study design:
SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24/48/72 h
Score:
ca. 3
Max. score:
4
Reversibility:
not reversible
Remarks:
after 8 d
Remarks on result:
other: after 20h exposure period
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Remarks:
after 8 d
Remarks on result:
other: after 20h exposure period
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: after 20h exposure period
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: after 20h exposure period
Irritant / corrosive response data:
No effect 1, 5 and 15 min after application

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information