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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Gassner
Sex:
male/female
Details on test animals and environmental conditions:
Mean body weights for male animals 202 g, for female animals 174 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
The test substance was administered as a 16%, 2% or 1% aqueous solution.
Doses:
50, 100, 125, 160, 200, 1600 µL/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
140 other: µl/kg
Based on:
test mat.
Mortality:
50 and 100 µL/kg bw: no mortalities
125 µL/kg bw: 1/5 males and 0/5 females after 7 days
160 µL/kg bw: 5/5 males and 2/5 females after 7 days
200 µL/kg bw: 4/5 males and 5/5 females after 7 days
1600 µL/kg bw: 5/5 males and 5/5 females after 7 days
Clinical signs:
apathy, dyspnea
Gross pathology:
acute heart dilatation, acute congestive hyperemia; liver: loam-grey spotted with blunted margins; kidneys: brightened complexion; stomach: bloody ulcerations, ascites, slight lung edema.

Any other information on results incl. tables

µL = mg (densitiy 0.996 g/mL)

Applicant's summary and conclusion