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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, predated OECD guideline, but scientifically fully acceptable and well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF- Test:acute inhalation toxicity with rats exposed to a saturated atmosphere for max. 8h
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks:
200 L/h
Analytical verification of test atmosphere concentrations:
no
Remarks on duration:
1 - 8 h
Concentrations:
saturated atmosphere
No. of animals per sex per dose:
20°C: 12 for the 8-hour exposure
40°C: 12 for the 1-hour exposure, 6 for the 3-hour exposure and 6 for the 8-hour exposure
Control animals:
no
Details on study design:
The test substance was offered as a vapour at 20°C resp. 40°C.

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: Mortality 0/12 (40°C)
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
3 h
Remarks on result:
other: Mortality 3/6 (40°C)
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: Mortality 6/6 (40°C)
Mortality:
20°C: no deaths after 8 hours.
40°C: no deaths after 1-hour exposure, 3 animals died after 3-hour exposure and all (6) animals died after 8-hour exposure.
Clinical signs:
Attemption to escape, irritation of the mucous membrane at 20°C.
Attemption to escape, irritation of the mucous membrane, dyspnea, apathy, staggering and tremor at 40°C.
Gross pathology:
Pulmonary congestion, congestion in the liver, degeneration of the liver, heart dilatation.

Applicant's summary and conclusion