Registration Dossier
Registration Dossier
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EC number: 231-388-1 | CAS number: 7526-26-3
Endpoint summary
Administrative data
Description of key information
The substance was predicted negative for skin sensitisation by the SciQSAR model (Danish QSAR database), which is implemented in the OECD QSAR Toolbox v4.5. The prediction falls into the applicability domain of this model.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 23 May 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OECD QSAR Toolbox v4.5, Danish QSAR database
2. MODEL (incl. version number)
SciQSAR version 3.1.00
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CP(=O)(Oc1ccccc1)Oc1ccccc1
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to attached QMRF
5. APPLICABILITY DOMAIN
Please refer to attached QPRF - Guideline:
- other: ECHA Guidance R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: OECD QSAR Toolbox v4.5, Danish QSAR database
- Model(s) used: SciQSAR version 3.1.00
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification' - Justification for non-LLNA method:
- QSAR model based on guinea pig and human data
- Specific details on test material used for the study:
- CP(=O)(Oc1ccccc1)Oc1ccccc1
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was predicted negative for skin sensitisation by the SciQSAR model (Danish QSAR database).
- Executive summary:
The substance was predicted negative for skin sensitisation by the SciQSAR model (Danish QSAR database), which is implemented in the OECD QSAR Toolbox v4.5. The prediction falls into the applicability domain of this model.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Three in vitro studies according to OECD Guideline 442 C/D/E have been ordered in a CRO to improve the dataset for this endpoint.
Justification for classification or non-classification
According to the prediction, the registered substance is not subject to classification and labelling according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
