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EC number: 208-584-0
CAS number: 534-03-2
Skin: not irritatingEye: corrosive
A skin irritation study (Lister, 1995c) was performed according to 40
CFR, Part 798, Subpart E Section 798.4470, Toxic Substances Control Act,
1994). The test substance was applied to the shaved skin of 6 rabbits
and covered with a semi-occlusive dressing for 4 hours. None of the 6
test animals exhibited any signs of erythema or edema during the 72-hour
These findings were confirmed in the acute dermal toxicity study
performed by Lister (1995). In this study APD was administered to rats
as a single dose of 2000 mg/kg bw under occlusive conditions for 24
Therefore, APD is considered not to cause skin irritation under the
conditions of these studies.
An eye irritation study was performed using the test substance on
rabbits, according to 40 CFR, Part 798, Subpart E Section 798.4500,
Toxic Substances Control Act, 1985 (Lister, 1995d). APD was instilled
into the eye of the animals and left without washing the eye at any time
point. All 6 animals exhibited irritation of the exposed eye and 4/6
developed pannus (corneal vascularisation) within 96 hours. As this is
an irreversible effect, the study was terminated after 96 hours. In
conclusion, the substance was corrosive to the eye under the conditions
of this study.
Effects on eye irritation: corrosive
The available data on skin irritation of the test substance do not meet
the criteria for classification according to Regulation (EC) 1272/2008
or Directive 67/548/EEC, and are therefore conclusive but not sufficient
for classification. The available data on eye irritation of the test
substance meet the criteria for classification as Category 1 (H318)
according to Regulation (EC) 1272/2008 and as Xi R41 according to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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