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EC number: 208-584-0
CAS number: 534-03-2
Oral (TSCA, 40 CFR, 798.1175), rat: LD50 = 5000 mg/kg bw Dermal (TSCA, 40 CFR, 798.1100) , rat: LD50 > 2000 mg/kg bw
Acute toxicity: oral
In an acute oral toxicity limit test (Lister, 1995a), performed
according to 40 CFR, Part 798, Subpart A, General Toxicity Testing,
Acute Oral Toxicity, 798.1175, Toxic Substances Control Act, July 1989,
10 rats were administered 5000 mg/kg bw 2 -amino-1,3 -propanediol (APD)
by gavage. 4/10 animals died, while piloerection and lethargy was
observed in 10/10 animals. Gross pathology examination indicated that
all the animals that died had discoloration in the liver, spleen,
kidneys and small intestine, and hemorrhaging in the stomach. The local
effects in the stomach were probably caused by the alkaline pH of the
test substance. The LD50 is considered to be = 5000 mg/kg bw.
Acute toxicity: dermal
An acute dermal toxicity limit test (Lister, 1995b) was performed with 2
-amino-1,3 -propanediol (APD) according to 40 CFR, Part 798, Subpart B
Section 798.1100, Toxic Substances Control Act, 1985. Rabbits were
exposed to 2000 mg/kg bw APD under semiocclusive conditions for 24
hours. There was no mortality. Nine of ten animals showed slight to
defined erythema at the test site after 24 hours, while 1 rabbit had
edema at the 24 -hour reading time point. The LD50 is therefore
considered to be > 2000 mg/kg bw.
The test substance-related findings were comparable for oral and dermal
routes of application in the acute toxicity studies, with the high
LD50-values indicating that APD has a very low potential to cause acute
toxicity via these routes.
The available data on acute toxicity of the test substance do not meet
the criteria for classification according to Regulation (EC) 1272/2008
or Directive 67/548/EEC, and are therefore conclusive but not sufficient
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