Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-584-0
CAS number: 534-03-2
Based on all available data of the substances within the chemical category, the weight of evidence demonstrates that the substances in this chemical category seem highly unlikely to be carcinogenic and are not classifiable as carcinogens. Further testing is not required under Regulation (EC) 1907/2006, Annex XI, section 1.2.
Based on all available data of the substances
within the chemical category, no carcinogenic potential is expected. The
available data do not meet the criteria for classification according to
Regulation (EC) 1272/2008 or Directive 67/548/EEC, and therefore are
conclusive but not sufficient for classification.
There are no animal data available on carcinogenicity or chronic
toxicity of 2-amino-1,3-propanediol (APD) or within the chemical
category APD belongs to. The members forming the chemical category are
APD, 2-amino-2-methyl-1,3-propanediol (AMPD) and
2-amino-2-ethyl-1,3-propanediol (AEPD). Due to the structural similarity
between the members of the category and the similar toxicological
properties, APD, AMPD and AEPD form a robust chemical category and
read-across within the chemical category is justified.
The modelling of potential metabolites via the OECD QSAR toolbox
v.2.0 (2010) did not predict relevant metabolites of the category
members. Based on the chemical structure of the parental compounds, no
metabolism is expected. Therefore, it can be assumed that
aminopropandiols will not show reactive properties under in-vitro and
in-vivo test conditions.
The category members are of low concern with regard to systemic
toxicity. Available studies via the oral, dermal and intraperitoneal
route indicate low acute and repeated dose toxicity. Inhalation is of no
concern, because the low vapour pressure means that exposure is unlikely
to occur.The results of the acute
studies, as well as the repeated dose studies, demonstrate that the main
cause of toxicity was the
intrinsic alkalinity of the category members at the site of contact.The
Cramer classification (related mainly to the oral route) also indicates
a low toxicological concern for all the category members. No metabolism
by cytochrome P450 enzymes in-vivo is expected; this is supported by
predictions from QSAR modelling.
Furthermore, the category members were not mutagenic or
clastogenic in the available genetic toxicity studies, bear no
structural similarity to known carcinogens, have no functional groups
associated with carcinogenicity and did not produce evidence of
neoplasia in repeated dose toxicity studies. Therefore it is concluded
that the category members do not have a carcinogenic potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again