Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-717-7 | CAS number: 12027-06-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The published literature fulfilled basically scientific principles without GLP compliance statement
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Summary of human data and estimation of TDI
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ammonium iodide
- EC Number:
- 234-717-7
- EC Name:
- Ammonium iodide
- Cas Number:
- 12027-06-4
- Molecular formula:
- H4IN
- IUPAC Name:
- ammonium iodide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Data available only for potassium/sodium iodide (similar inorganic iodides)
The toxicity of ammonium iodide also come from iodide.
Test animals
- Species:
- other: human data
- Strain:
- other: human data
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- In the "details on oral exposure"
- Frequency of treatment:
- In the "details on oral exposure"
Doses / concentrations
- Remarks:
- Doses / Concentrations:
In the "details on oral exposure"
Basis:
no data
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 0.01 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Other
- Dose descriptor:
- other: tolerable daily intake (TDI)
- Effect level:
- 0.01 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: A TDI of 0.01 mg/kg body weight, based upon reversible subclinical hypothyroidism, can be established by dividing the NOAEL of 0.01 mg/kg body weight per day by an uncertainty factor of 1.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Data available only for potassium/sodium iodide (similar inorganic iodides)
The toxicity of ammonium iodide also come from iodide.
TDI of iodide is 0.01 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
