Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation (in vitro, GLP, OECD TG404/431): not irritating
[Schering AG, Report A25420; 2006-09-27]
Eye irritation (Rabbit-NZW, GLP, non-audited report, OECD TG405): not irritating
[Schering AG, Report No. X168; 1996-10-07]

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

ZK 5894 was tested for its skin irritation and corrosive properties using a reconstituted epidermis model. ZK 5894 was non-irritating and non-corrosive under the conditions of this study. [Schering AG, Report A25420; 2006-09-27] ZK 5894 provoked slight to moderate transient irritations (secretion; reddening of outer eyelids and eyelid closure; reddening, swelling and vascular injection of the conjunctivae) in the rabbit eye after single conjunctival application on the day of administration. From day 3 onwards, all animals were without findings. ZK5894 is not regarded as an eye irritant. [Schering AG, Report No. X168; 1996-10-07]

Justification for classification or non-classification

Based on the results there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).