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REACH

17β-hydroxy-1α-methyl-5-αandrostan-3-one acetate

EC number: 223-768-0 | CAS number: 4062-46-8

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Key value for chemical safety assessment

Additional information

ZK 5894 did not show a mutagenic potential in a bacterial reverse mutation assay (Ames test in S. typhimurim strains TA 98, TA 100, TA 102, TA 1535, TA 1537 and E. coli strain WP2uvrA) when tested up to the highest recommended dose level of 5.0 mg/pate in the absense or presense of extrinsic metabolic activation (liver S9 mix from Aroclor 1254 -treated rats). [Schering AG, Report A25157; 2006-01-16]

Short description of key information:
Gene mutation (bacterial reverse mutation assay / Ames test, GLP, OECD TG471): negative with and without metabolic activation
[Schering AG, Report A25157; 2006-01-16]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Not classified according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) criteria since no genotoxic potential in vitro (Ames test).

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