Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Contact dermatitis dur to spandex
Author:
Van Dijk E.
Year:
1968
Bibliographic source:
Acta Derm.Venereol. 48, 589-591.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-diphenylguanidine
EC Number:
203-002-1
EC Name:
1,3-diphenylguanidine
Cas Number:
102-06-7
Molecular formula:
C13H13N3
IUPAC Name:
1,3-diphenylguanidine
Details on test material:
no data

Method

Type of population:
general
Subjects:
3 Women who have bra or brassiere with spandex.
Ethical approval:
confirmed, but no further information available
Route of exposure:
dermal
Reason of exposure:
unintentional, non-occupational
Details on exposure:
Exposure to spandex which contains DPG, e.g. brassiere, bra.
Examinations:
3 patients presented dermatitis.

Results and discussion

Clinical signs:
3 patients with contact dermatitis due to Spandex (a synthetic polyurethane elastomer) were tested; one patient showed a positive reaction to DPG (2 % in petrolatum) with erythema, edema, papules and vesicles.

Applicant's summary and conclusion

Conclusions:
3 patients with contact dermatitis due to Spandex (a synthetic polyurethane elastomer) were tested; one patient showed a positive reaction to DPG (2 % in petrolatum) with erythema, edema, papules and vesicles.