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EC number: 203-002-1
CAS number: 102-06-7
Williams (1984) studied the effect of 1,3
-diphenylguanidine on the growth of soil micro-organisms. The compound
was spread on a polycarbonate membrane or imbedded on aluminiun foil in
an epoxy resin (Araldit), and was thus in indirect (via membrane pores)
or direct contact with a not further specified soil (moistened John
Innes N°.1 soil). No colonies formed during the 3 -month experiment.
The compound was also placed in nutrient agar, inoculated
with an aquaeous soil extract (3.0E07 individuals/ml) and incubated for
4 and 14 days at 25°C. The LD50 for both incubation times was given as >
or = 0.1%, based on the growth rate of control experiments. This
concentration was characterized by the author as highly toxic, although
when converted it corresponds to an amount of < or = 1 g/l. The author
pointed out that experiments of this type are not suitable for
evaluating the microbial degradation of rubber (and thus the microbial
toxicity of the rubber chemicals added) as they do not consider the
chemical change of the test compound during vulcanization.
According to claimed uses of 1,3 -diphenylguanidine soil
exposure is likely. At the moment no relevant data is available for
characterizing its effects on micro-organisms inhabiting soils. As the
risk assessment demonstrates that there is no risk for those organisms
using the PNEC derived through equilibrium partitioning method, no test
is needed for covering this question.
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