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EC number: 211-334-3
CAS number: 638-38-0
one-generation reproduction study (equivalent to OECD 415 with
deviations), Manganese sulphate was administered to 10 Crl:CD(SD)BR rats
per sex and dose by inhalation of 0, 0.15, 1.53 and 3.1 mg/m³ over
6h/day, 7days/week. Additionally, each 5 males and females per litter
were exposed with the dam. The effects of MnSO4 on the newborn pups are
considered to be sufficient to assess its teratogenic effects.
no relevant compound related toxic effects in the main categories of
systemic, reproductive or developmental toxicity evaluated. No relevant
LOAEC could be observed. The NOAEC was determined from the highest dose
level tested as ≥
mg/m³ for both dams or offspring.
study is acceptable and satisfies with restrictions the guideline
requirement for a one-generation reproductive study (OECD 415) in rats
which also allows the assessment of the teratogenic effects of Manganese
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