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EC number: 211-334-3
CAS number: 638-38-0
Manganese (II) actetate has a low potential for bioaccumulation, which is only due to the Mn2+ cation. Manganese is a required trace element and acetate is a common metabolite in many metabolic pathways.
order to assess the toxicological behaviour of Manganese (II) acetate,
the available physico-chemical and toxicological data have been
evaluated. The substance is expected to be well absorbed after oral
exposure. Concerning the absorption after exposure via inhalation, as
the chemical has a really low vapour pressure, a decomposition
temperature and is furthermore distributed as aqueous solution; it is
clear, that the substance has a low availability for inhalation.
However, in case inhalable dusts are formed by the less present
water-free salt, inhalative absorption has to be considered. The
substance has only a low bioaccumulative potential, which is only due to
the manganese cation. Its absorption during normal environmental or
slightly elevated exposure does not bear any potential for adverse
effects, because Manganese is also a required trace element to maintain
the normal functionality of the body and acetate is a common metabolite
in many metabolic pathways.
present expert statement covers all relevant toxicokinetic parameters to
assess the behaviour of manganese (II) acetate (Mn(acO)2) in the body,
the available information is sufficient to enable one to perform a
proper risk assessment. Hence, no further information needs to be
gathered, all data requirements under REACH are fulfilled and further
studies can be omitted due to animal welfare. In conclusion, Mn(acO)2
has only a low potential for bioaccumulation, and its absorption during
normal environmental or slightly elevated exposure does not bear any
potential for adverse effects but is also required to maintain the
normal functionality of the body.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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