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EC number: 211-334-3
CAS number: 638-38-0
a dermal sensitization study similar to OECD 429 (murine local lymph
node assay) with manganese chloride (25, 10, 5 % (w/v)) and lead acetate
(10, 5, 2.5 % (w/v)) in petrolatum resp. DMSO, 7-12 week old CBA/Ca mice
(4 animals / dose group) were tested using the ³H-thymidine
incorporation method. The test substance was applied on three
consecutive days on the dorsum of each ear, local lymph nodes were
isolated on the fifth day, 5 h after ³H-thymidin was injected in the
tail vein, and beta-scintillation was measured. No clinical signs and
mortality was recorded. The stimulation index (SI) was determined to be
0.6 – 1.1 for both substances, so manganese (II) acetate is not a dermal
sensitizer. This study is considered to be reliable and to fulfill the
requirements for a study similar to OECD 429.
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