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EC number: 905-562-9
CAS number: -
The lowest result is a 24 hour EC50 of 1
mg/L for o-xylene (Galassi 1988). The estimated LL50 values from TLM
QSAR were 8.730 - 11.076 mg/L.
The experimental value was used for chemical
available on the acute toxicity of each of the xylene isomers and
ethylbenzene to aquatic invertebrates. The study by Galassi et al (1988)
follows OECD 202 and uses Daphnia magna, whilst Holcombe et al
(1987) used a flow through system to expose different species (including Daphnia
magna) simultaneously. Niederlehner et al (1998) used Ceriodaphnia
dubia as the test organism. All studies included analytical
confirmation of the exposure concentrations.
The lowest result
listed in the EU RAR (ECB 2007) and the Draft Screening Assessment
Report (Environment Canada 2014) for acute toxicity of ethylbenzene to
invertebrates is a 48 hour EC50 of 1.8 mg/L (Vigano 1993). The ECB
report that the study investigated the toxicity of ethylbenzene to Daphnia
magna in completely filled, closed bottles, with results based on
mean measured concentrations. The results were taken from a larger study
on the effects of different food rations on juvenile Daphnia.
Although lower results are reported by Benville and Korn (1977) are
reported in the EU RAR, the test result is not considered valid as it is
not known how the mean exposure concentration over the whole test
duration was calculated and no attempt was made to supplement the
The 24 and 48
hour EC50 results reported from these studies for the xylene isomers and
ethylbenzene are very similar, with a range of 1 - 4.7 mg/L. In the
study by Niederlehner et al (1998) the highest concentration tested did
not result in effects on mortality, therefore the EC50 is > 3.4 mg/L.
The lowest result will be used in the risk assessment.
A TLM-EqP modeling framework was used to
support values derived experimentally and are presented as supporting
The estimated LL50 values from TLM QSAR were
8.730 - 11.076 mg/L
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