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EC number: 905-562-9
CAS number: -
ecotoxicity data are not available for the Reaction Mass of Ethylbenzene
and m- and p-Xylene. However, complete acute datasets are available for
constituent substances o-, m-, and p-xylene isomers and and
ethylbenzene. Data from a chronic fish study are available for mixed
xylenes. Data from chronic invertebrate and algal studies are available
for m and p xylene and ethylbenzene. As
these test materials are components of the Reaction Mass of Ethylbenzene
and m- and p-Xylene it is believed it is appropriate to read across the
the xylene isomers are structurally similar substances, consisting of a
benzene ring with one and two methyl functional groups attached
respectively; the different xylene isomers having the two methyl
functional groups attached at different locations. The presence and
position of the second methyl functional group on the benzene ring is
not expected to change the ecotoxicity properties of the substance
significantly. The similarities in the physico-chemical properties of
the components of the stream indicate that the ecotoxicity of the
components is likely to be similar. All of the components are relatively
soluble in water, with limited potential partition coefficients. The
water solubility (Yalkowsky and He 2003) and log partition coefficient
(Hansch et al. 1995) of ethylbenzene, m-, o- and p-xylene are 190.7 mg/L
and 3.15, 146 mg/L and 3.2, 170.5 mg/L and 3.12, and 156 mg/L and 3.15
The data on the
xylene isomers has been taken from proprietary studies or published
journal articles, for which the original sources have been reviewed. A
literature search was undertaken and data were evaluated for relevance
and reliability using the Klimisch scoring system (Klimisch 1997).
Sufficient reliable data were identified for completion of the
ecotoxicity sections of the REACH registration dossiers for the
individual xylene isomers and the data has been used for the hazard
assessment of the streams.
A data search on
ethylbenzene identified published studies and regulatory review
documents. As ethylbenzene is used as a marker substance for the streams
in this category, it was considered suitable to use the review documents
as reliable secondary sources for inclusion as additional evidence,
without evaluating the original studies.
The European Risk
Assessment Report (ECB 2007) was prepared by the German Competent
Authority and interested companies following the methods set out in
Commission Regulation (EC) 1488/94 and the associated Technical Guidance
Document. The document has been peer-reviewed by the Scientific
Committee on Health and Environmental Risks (SCHER) and therefore the
report is considered to be a reliable source of information. Only
studies which addressed the volatility of ethylbenzene (using flow
through or closed systems with analytical measurement) were considered
for inclusion in the review of the aquatic ecotoxicity data.
Screening Assessment Report (Environment Canada 2014) was prepared by
the Existing Substances programs at Health Canada and Environment Canada
and has undergone external written scientific peer review/consultation.
Data were taken from recent literature searches (up to December 2009 for
ecological sections) and review and assessment documents. When available
and relevant, information presented in hazard assessments from other
jurisdictions was considered. The key studies were critically evaluated,
with the screening assessment presenting the most critical studies and
lines of evidence pertinent to the conclusion.
According to the TLM QSAR modelling, the
most sensitive species for both short term (LL50) and long term (NOELR)
endpoints was Oncorhynchus
mykiss, with a range of LL50 values between 4.667 - 5.921 mg/L, and
a range of NOELR values between 0.894 - 1.134 mg/L. In both cases
m-xylene was the test material with the lowest values.
References (not included as dossier
Klimisch, H.J., Andreae, M. and Tillmann, U.
(1997) A systematic approach for evaluating the quality of experimental
toxicological and ecotoxicological data. Regulatory toxicology and
pharmacology, 25(1), pp.1-5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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