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EC number: 905-562-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP status not known, near guideline study, published in peer reviewed literature, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicological properties of hydrocarbon solvents
- Author:
- Hine CH, Zuidema HH
- Year:
- 1 970
- Bibliographic source:
- Industrial Medicine 39, 215-200.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Principles of method if other than guideline:
- Groups of 10 male rats were exposed to (unspecified) concentrations of C-8 aromatics for 4 hours followed by a 14 day observation period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- mixed xylenes
- EC Number:
- 924-522-1
- IUPAC Name:
- mixed xylenes
- Reference substance name:
- Xylene
- EC Number:
- 215-535-7
- EC Name:
- Xylene
- Cas Number:
- 1330-20-7
- Molecular formula:
- C8H10
- IUPAC Name:
- xylene
- Details on test material:
- C-8 aromatics (ortho, meta and para xylene, ethylbenzene composition not defined). Boiling range 138-141°C.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Body weight 150 - 300 g.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- A 250 L chamber was used for the vapour exposures. Air entering the chamber was bubbled through the sample, heated to 25°C in a water bath in order to obtain an atmosphere as close to saturated as possible. Vapour concentration in the chamber was monitored by means of a Wilkens Aerograph GLC and compared with the vapour concentration obtained from a bottle known to contain vapours saturated at 25C. For graded concentrations less than saturated, the air flow entering the chamber was divided so that only part of it passed through the sample. Rats were exposed for four hours and ten rats were used for each exposure.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- not stated
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Animals were retained for a minimum of 14 days after exposure and mortality values were based on the number of animals which died during this interval.
- Statistics:
- LD50 values were determined by the method of Litchfield and Wilcoxon
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 6 350 ppm
- 95% CL:
- 4 670 - 8 640
- Exp. duration:
- 4 h
- Remarks on result:
- other: 27571 mg/m3
- Mortality:
- All deaths (number not reported) occurred during exposure.
- Clinical signs:
- other: Survivors were comatosed but recovered shortly following removal from the chamber.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The inhalation LC50 was 6350 ppm in the rat.
COMMENT TO TSC: conversion to mg/L required once phys-chem properties confirmed. - Executive summary:
Groups of male rats were exposed to (unspecified) concentrations of C-8 aromatics for 4 hours followed by a 14 day observation period. All exposures caused CNS depression (animals described as being in a comatose state), with an overall LC50 of 6350 ppm.
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