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EC number: 905-562-9
CAS number: -
comparison of the incidence of skeletal variations
based on Saillenfait AM et al, 2003, Food and Chemical Toxicology 41
Exposure level (ppm)
Total no foetuses (litters)
No (%) foetuses with skeletal variations
47 (35.1) ##
Mean % foetuses with skeletal variations per litter
36.7 ±24.4 **
## Significant difference from control (air), P < 0.01 Fisher's test.
** Denotes significant difference from control (air), P < 0.01, Mann-Whitney test.
Inhalation exposure of Sprague-Dawley rats
to 0, 100, 500, 1000 or 2000 ppm o-xylene from gestation days 6 -20
resulted in maternal toxicity at 1000 (4.4 mg/L) and 2000 ppm (8.8 mg/L). Foetal
toxicity at 1000 and 2000 ppm, in the presence of maternal toxic effects
was seen. There was a 5% difference in foetal weight
at 500 ppm (2.2 mg/L), which is considered to be of limited biological
relevance, and o-xylene was not teratogenic up to 2000 ppm.
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