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EC number: 905-562-9
CAS number: -
and female Crl:CD(SD)IGS BR rats were exposed by inhalation to 0, 25,
100 or 500 ppm ethylbenzene for 6 hr/day throughout a 2-generation study
except for females between lactation days 1 and 4 when the dose was
administered in corn oil by oral gavage at dose levels of 26, 90 or 342
mg/kg/day (to provide similar maternal blood (AUC) as provided by
physical and neurobehavioural development of the F2-generation was
evaluated using a number of developmental landmarks, a functional
observational battery, a motor activity assessment, an acoustic startle
response and a learning and memory task. Evaluations of whole-brain
measurements and brain morphometric and histological assessments were
exposure to ethylbenzene at concentrations up to and including 500 ppm
did not adversely affect the survival of the F2 offspring, their
clinical condition or body weight or their acquisition of several
developmental landmarks. No
treatment-related alterations were detected in the FOB tests, the motor
activity counts, acoustic startle endpoints or the performance in the
Biel water maze. Furthermore,
no exposure-related differences were evident from the neuropathology
assessments. The NOAEC for physical and neurobehavioural development was
500 ppm ethylbenzene.
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