Registration Dossier
Registration Dossier
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EC number: 220-822-5 | CAS number: 2909-38-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Acute oral toxicity study in male Wister rats.
- GLP compliance:
- not specified
- Test type:
- other: Acute oral toxicity study in male Wister rats
- Limit test:
- no
Test material
- Reference substance name:
- 3-chlorophenyl isocyanate
- EC Number:
- 220-822-5
- EC Name:
- 3-chlorophenyl isocyanate
- Cas Number:
- 2909-38-8
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-3-isocyanatobenzene
- Details on test material:
- liquid substance, no data on purity or further data on test material given.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.5, 1.0, 3.1, 4.0, 4.5, 5.0 ml/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.61 mL/kg bw
- Remarks on result:
- other: Following symptoms of toxicity could be observed in the animals tested: diminuated general condition, cyanosis, narcosis, scrubby fur and bloody eyes and nose.
Any other information on results incl. tables
Results:
| Toxicological results | ||||||||||||||
| Dose (ml/kg) | sex | died animals | Symptom. animals | animals used | Timepoint of death | starting point of symptoms | Diminuated general condition | Diarrhea | Cyanosis | Heightened diuresis | face-down/lateral position | Narcosis | Scrubby fur | Bloody eyes and nose |
| 0.5 | male | 0 | 0 | 10 | / | / | / | / | / | / | / | / | / | / |
| 1.0 | male | 3 | 10 | 10 | 2 -11d | 24h | + | / | / | / | / | + | + | / |
| 3.1 | male | 4 | 10 | 10 | 2d | 30 min | + | / | + | / | / | + | + | / |
| 4.0 | male | 5 | 10 | 10 | 4h-2d | 30 min | + | / | + | / | / | + | + | + |
| 4.5 | male | 7 | 10 | 10 | 2 -3d | 30 min | + | / | + | / | / | + | + | + |
| 5.0 | male | 10 | 10 | 10 | 2d | 30 min | + | / | + | / | / | + | + | / |
Applicant's summary and conclusion
- Executive summary:
In an acute oral toxicity study in male Wistar rats the animals were treated once via gavage with following doses of test substance: 0.5, 1.0, 3.1, 4.0, 4.5, 5.0 ml/kg bw. Following symptoms of toxicity could be observed in the animals tested: diminuated general condition, cyanosis, narcosis, scrubby fur and bloody eyes and nose.
The LD 50 was found to be: 2.61 ml/kg bw.
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