3-chlorophenyl isocyanate

Endpoint summary

Description of key information

Acut oral: LD50 rat; male: 2.61 ml/kg bw (Löser, 1981);
 Acut inhalation:  LC 50 rat; male female: 42 mg/m³ air (LC 50 male: 58 mg/m³air; LC 50 female: 39 mg/m³) (Pauluhn, 1991).
 Acut dermal: LD50 rat, male: >2.5 ml/kg (Löser, 1982).

Additional information

In an acute oral toxicity study in male Wistar rats the animals were treated once via gavage with following doses of test substance: 0.5, 1.0, 3.1, 4.0, 4.5, 5.0 ml/kg bw. Following symptoms of toxicity could be observed in the animals tested: diminuated general condition, cyanosis, narcosis, scrubby fur and bloody eyes and nose.

The LD 50 was found to be: 2.61 ml/kg bw (Löser, 1981).

In an acute oral toxicity study in male and female rats according OECD guideline 403 the animals were exposed for 4h to following concentrations of test substance: 8, 39, 77, 150, 181 mg/m³. The observation period was 4 weeks.

The LC50 for male and female rats was 42 mg/m³ air (LC 50 male: 58 mg/m³air; LC 50 female: 39 mg/m³) (Pauluhn, 1991).

In an acute dermal toxicity test in male rats the test substance was applied once to the skin of the animals. The doses tested were: 1.0 and 2.5 ml/kg bw. The observation period was 14 days. Following signs of toxicity were observed: skin-necrosis, loss of body weight, pain-sensation and diminuation of general condition.

The LD50 was found to be >2.5 ml/kg bw (Löser, 1982).

Justification for classification or non-classification

The LC 50 of 42 mg/m³ leads to a classification requirement of R26.

No classification for acute oral or dermal toxicity required.