Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 936-023-6 | CAS number: 950782-86-2
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Indaziflam
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Related composition:
- Indaziflam
- Reference substance:
- Indaziflam
- Reference substance:
- Indaziflam
- Name:
- Indaziflam
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- Indaziflam
- Reference substance:
- Indaziflam
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Summary PBT assessment
The PBT assessment of the substance is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (2017).
Persistence assessment
The substance is not readily biodegradable following the screening criteria according to OECD and mineralization in surface water is negligible (DT50 > 1000 days at 20°C). If released into natural water the substance is quickly eliminated from the water body, by translocation into the sediment (DT50 water 2.7 – 4.8 days at 20 °C). The DT50 values for the substance in the entire water-sediment systems were determined to range between 126.7 days and > 365 days at 20 °C under aerobic conditions. Also in soil the parent substance degrades under aerobic conditions. The determined half life time in soil ranged from 22 to 177 days at 20-25 °C. No transformation products were formed under anaerobic conditions.
Therefore, the substance does meet the P and vP criterion.
Bioaccumulation assessment
Results of a BCF study reveal that the substance does not show significant accumulation in aquatic organisms. Due to rapid depuration, the potential for biomagnification through the food chain is low as indicated by a flow-through bioaccumulation and metabolism study with Bluegill Sunfish (Lepomis macrochirus) with a BCF (whole fish) of 16, and the steady-state BCF for the substance normalized to 6% lipid content is 11. The available information indicates that the substance has a very low potential for bioconcentration and will not accumulate to significant levels in aquatic organisms.
Therefore, the substance does not meet the B criterion.
Toxicity assessment
From the ecotoxicity perspective the toxicity criterion is met for the substance with a lowest NOEC of 0.00032 mg/L (plants, mesocosm) being below the ecologically relevant NOEC triggers of less than 0.01 mg/L.
Thus, the substance meets the T criterion.
In conclusion, the substance is not PBT/vPvB.
Referenceopen allclose all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
