Registration Dossier
Registration Dossier
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EC number: 233-658-4 | CAS number: 10294-34-5
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
There are no indications to justify a classification of BCl3 as carcinogenic.
Additional information
A contact of BCl3 with water is required before it can exert systemic toxic actions. BCl3 is rapidly degraded in water to hydrogen chloride and boric acid. A degradation category approach is applied, see Section 13.
Hydrogen chloride:
Daily exposure of rats to gaseous hydrochloric acid at the concentrations of 10 ppm, 6 hours a day, 5 days per week up to 128 weeks did not affect the survival or body weight of exposed animals. A higher incidence of hyperplasia of the larynx and trachea was noted at histopathology, compared to air and colony control groups. No serious irritating effects in the nasal epithelium were observed. None of the treated animals developed any preneoplastic or neoplastic lesions indicating a lack of carcinogenic activity.
Boric acid:
A 2 year carcinogenicity study was performed in mice and oral dosing. Boric acid was non-oncogenic. NOAEL = 1150 mg/kg bw/d.
Endpoint conclusion:
BCl3 is considered to be non-carcinogenic.
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