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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: An old publication with few details on the method used.

Data source

Materials and methods

Principles of method if other than guideline:
No data available.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
200 - 300 g body weight.
Mice were also used: Strain CF-1, male, 22-28 g.

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
1 h

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
2 541 ppm
Based on:
test mat.
95% CL:
2 243 - 2 878
Exp. duration:
1 h
Remarks on result:
other: For rats.
Sex:
male
Dose descriptor:
LC50
Effect level:
4 418 ppm
Based on:
test mat.
95% CL:
3 940 - 4 953
Exp. duration:
1 h
Remarks on result:
other: For mice.
Mortality:
No data are available.
Clinical signs:
other: No data are available.
Body weight:
No data are available.
Gross pathology:
No data are available.
Other findings:
No data are available.

Any other information on results incl. tables

For the original results see the attachment.

Applicant's summary and conclusion

Conclusions:
An LC50,1h of 2541 ppm was obtained from an experiment with the BCl3-gas and rats..
Executive summary:

An acute inhalation toxicity study with rats was performed with a lot of substances. Mice were used too. For boron trichloride an LC50,1h,rat = 2541 ppm was obtained.