Registration Dossier

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A degradation category approach is applied, based on the very rapid hydrolysis of boron trichloride. The description and justification of the category is presented in Section 13.
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Materials and methods

Principles of method if other than guideline:
A category approach is applied.

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
BCl3 is degraded to hydrogen chloride and boric acid when coming into contact with biological membranes, such as skin or mucous membranes in the respiratory tract.
HCl will act locally and is corrosive. HCl is not expected to be systemically available. Dissociated to H+ and Cl-, it is naturally available in the organism in access to a possibly artificially dosed HCl.
Boric acid is well absorbed by inhalation and orally, but to only a low degree through the skin. It is distributed evenly in the body and is rapidly excreted, mainly with urine.
Executive summary:

BCl3 is degraded to hydrogen chloride and boric acid when coming into contact with biological membranes, such as skin or mucous membranes in the respiratory tract. A degradation category approach is therefore applied, see also Section 13.

HCl will act locally and it is corrosive. HCl is not expected to be systemically available. Dissociated to H+ and Cl-, it is naturally available in the organism, usually in access to a possibly artificially dosed HCl.

Boric acid is well absorbed by inhalation and orally, but to only a low degree through the skin. It is distributed evenly in the body and is rapidly excreted, mainly with urine.