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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 Sep 1995 to 23 Nov 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
May 1981
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
December 1992
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-0.13
Temp.:
25 °C
pH:
6.9
Conclusions:
The Log Pow of the test item is determined to be -0.13 (± 0.0017).
Executive summary:

The 1-octanol / water partition coefficient (Pow) of the test item has been determined using the shake flask method in accordance with OECD TG 107 and in compliance with GLP. The octanol / water partition coefficient (Pow) and its logarithm to base 10 (log Pow) were determined to be 0.73 (± 0.0029) and -0.13 (± 0.0017) respectively at 25 °C and pH 6.9.

Description of key information

Log Kow = -0.13 at 25 °C, OECD 107, flask method, Stulz 1995

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.13
at the temperature of:
25 °C

Additional information