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EC number: 428-650-4 | CAS number: 153719-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(2-chloro-thiazol-5-ylmethyl)-5-methyl-[1,3,5]oxadiazinan-4-ylidene-N-nitroamine
- Cas Number:
- 153719-23-4
- Molecular formula:
- C8H10ClN5O3S
- IUPAC Name:
- 3-(2-chloro-thiazol-5-ylmethyl)-5-methyl-[1,3,5]oxadiazinan-4-ylidene-N-nitroamine
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Remarks:
- SPF rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 weeks old
- Weight at study initiation: 212 to 230 g in males and 160 to 181 g in females
- Housing: Individually in stainless steel wire mesh cages
- Diet: A pellet diet ad libitum
- Water: Tab water ad libitum
- Acclimation period: Approximately 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 3
- Humidity (%): 50 ± 20
- Air changes: 11 to 13 minutes per hour
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: Start: 6 Oct. 1995 End: 23 May 1996
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- PRELIMINARY DERMAL TOXICITY STUDY
In a preliminary acute dermal toxicity study, a group of three male and three female 7 week old CD(SD) rats had the test article administered at a dose level of 2000 mg/kg bw. No deaths were observed in either sex and therefore a single dose of 2000 mg/kg bw of the test material was administered dermally to a group of 5 male and 5 female (both 7 weeks old) CD(SD) rats.
TEST SITE & TEST ARTICLE
On the day prior to application of the test article, the dorsal area (approximately 30cm2 5 x 6cm) of each animal was clipped with an electric clipper. Immediately before administration, requisite amount of the test article was weighed for each animal and impasted by addition of 0.5 mL of distilled water. The test article was applied evenly to a gauze sheet (approximately 20cm2 4 x 5cm), placed on the application site and then covered with a polyethylene-film plaster and fixed with surgical tape.
REMOVAL OF TEST SUBSTANCE
After 24 hours of application, the dressing was removed and the application site was wiped with a gauze sheet. The reaction sites were then assessed. - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Remarks:
- distilled water
- Details on study design:
- - Duration of observation period following administration: 14 days
- The animals were examined frequently for the first six hours after dosing and twice daily in the morning and afternoon thereafter for 14 days for mortality and clinical abnormalities during the study.
- Body weights were recorded throughout the study.
- At the end of the scheduled observation period, all animals were necropsied and examined macroscopically. - Statistics:
- For body weights, group mean values with standard deviation were calculated.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the study.
- Clinical signs:
- other: No abnormalities were observed in any animal.
- Gross pathology:
- No abnormalities were observed in any of the organs of the animals. Neither was there any change at the application site.
- Other findings:
- IRRITATION
There were no signs of irritability at the application site (dorsal skin).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of the test substance after a single dermal application to rats of both sexes, observed over a period of 14 days is greater than 2000 mg/kg body weight.
- Executive summary:
In an acute dermal toxicity study, groups of 7 week old Crj:CD (SD) strain SPF rats (each group consisting of 5 animals of each sex) were dermally exposed to the test substance (purity 98.60%) for 24 hours via a gauze sheet of 20 cm2 to the rodent dorsal area at doses of 0 or 2000 mg/kg bw. Animals then were observed for 14 days. The animals were examined frequently for the first six hours after dosing and twice daily in the morning and afternoon thereafter for 14 days for mortality and clinical abnormalities during the study. Body weights were recorded throughout the study. No death was observed in any animal at 2000 mg/kg bw. There were no treatment related clinical signs, necropsy findings or changes in body weight. The acute dermal LD50 of the test substance after a single dermal application to rats of both sexes, observed over a period of 14 days is in excess of 2000 mg/kg bw. In the clinical signs, no abnormalities were observed in any animal, nor was there any sign of irritability at the application site.
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