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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Jan 1998 to 24 Feb 1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline followed
Principles of method if other than guideline:
Experimental Procedure
Mixtures of the test substance with each of the investigated solvents were prepared in glass volumetric flasks. Sufficient substance was added to ensure that saturation was achieved. The contents of each flask were stirred for forty-eight hours at the test temperature of 25.0 °C (± 0.1 °C) in a thermostatically controlled water bath. After this time a representative aliquot from each flask was transferred to a stainless steel centrifuge tube. These tubes were then centrifuged for 40 minutes at 50000 G in a centrifuge, thermostated at 25.0 °C.

Analysis
After centrifugation each centrifuge tube contained a clear supernatant liquid - saturated solution - with a residue of undissolved, excess test substance still present. An aliquot from each clear, saturated solution was subsequently analysed by high performance liquid chromatography to determine the solubility of the test substance in each of the investigated solvents.
The analytical method is sufficiently precise and sensitive, and is specific with respect to known by-products and degradation products.
GLP compliance:
yes
Medium:
acetone
Solubility:
48 g/L
Temp.:
25 °C
Medium:
other: dichloromethane
Solubility:
110 g/L
Temp.:
25 °C
Medium:
ethyl acetate
Solubility:
7 g/L
Temp.:
25 °C
Medium:
other: hexane
Solubility:
< 1 g/L
Temp.:
25 °C
Medium:
methanol
Solubility:
13 g/L
Temp.:
25 °C
Medium:
n-octanol
Solubility:
620 mg/L
Temp.:
25 °C
Medium:
toluene
Solubility:
680 mg/L
Temp.:
25 °C
Test substance stable:
not determined
Executive summary:

The test was performed in compliance with GLP. The solubility of test substance in different organic solvents is presented below:

Acetone: 48 g/L

Ethyl acetate: 7 g/L

Dichloromethane: 110 g/L

Hexane: < 1 mg/L

Toluene: 680 mg/L

Methanol: 13 g/L

n-octanol: 620 mg/L

Description of key information

Stulz 1995

Key value for chemical safety assessment

Additional information

The solubility of test substance in different organic solvents is presented below:

Acetone: 48 g/L

Ethyl acetate: 7 g/L

Dichloromethane: 110 g/L

Hexane: < 1 mg/L

Toluene: 680 mg/L

Methanol: 13 g/L

n-octanol: 620 mg/L