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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February from 09th to 21st, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
adopted July 27, 1995
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Water solubility:
94 µg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7.2
Details on results:
The water solubility of test item was determined to be 0.09.4 x 10^-2 ± 0.0924 x 10^-2 mg/l (95 % confidence interval) at 20 ± 0.5 °C using the column elution method for the performance of the main test.

The measured concentrations are constant within ± 30 % and thus within the range required by the guidelines.

Results of the determination of water solubility of test item (flow rate: ca. 25 ml/hour)

Measured concentration (mg/l)
Column 1 Column 2
below the quantitation limit pH = 7.44 below the quantitation limit pH = 7.31
below the quantitation limit pH = 7.42 below the quantitation limit pH = 7.28
below the quantitation limit pH = 7.45 below the quantitation limit pH = 7.29
0.0622 pH = 7.40 0.0665 pH = 7.27
0.0701 pH = 7.38 0.0695 pH = 7.31
0.0961 pH = 7.23 0.0989 pH = 7.20
0.0977 pH = 7.19 0.1139 pH = 7.21
0.0939 pH = 7.15 0.0978 pH = 7.18
0.0888 pH = 7.07 0.0958 pH = 7.15
Mean / RDS: 0.0876 / 19 %

 pH 7.22 - 7 -24

Results of the determination of water solubility of test item (flow rate: ca. 12.5 ml/hour)

Measured concentration (mg/l)
Column 1. Column 2.
0.0978 pH = 7.19 0.1070 pH = 7.23
0.1088 pH = 7.20 0.1080 pH = 7.18
0.1221 pH = 7.20 0.1215 pH = 7.21
0.0916 pH = 7.17 0.1055 pH = 7.18
0.1072 pH = 7.13 0.0891 pH = 7.15
0.0961 pH = 7.14 0.1118 pH = 7.16
0.0759 pH = 7.10 0.0699 pH = 7.09
0.0830 pH = 7.10 0.0869 pH = 7.09
Mean / RDS: 0.0989 / 15 %

pH 7.15 - 7 .16

Conclusions:
Water solubility: 94 µg/l at 20 °C and pH ca 7.20
Executive summary:

The purpose of the study was to evaluate the solubility of test item in water at 20 ± 0.5 °C, according to the OECD guideline 105. The method chosen is based on the elution of the test substance with water from a micro-column, which is charged with an inert support material coated with an excess of test substance. The water solubility is determined when the mass concentration of the eluate is constant, i.e.concentration plateau as a function of time.

The water solubility of test item was determined to be 0.09.4 x 10^-2 ± 0.0924 x 10^-2 mg/l (95 % confidence interval) at 20 ± 0.5 °C using the column elution method for the performance of the main test. The measured concentrations are constant within ± 30 % and thus within the range required by the guidelines.

Conclusion

Water solubility: 94 µg/l at 20 °C and pH ca 7.20

Description of key information

94 µg/l at 20 °C and pH ca 7.20

Key value for chemical safety assessment

Water solubility:
94 µg/L
at the temperature of:
20 °C

Additional information

OECD 105 - column elution method