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EC number: 227-876-9
CAS number: 6021-61-0
A study was conducted to determine the
skin sensitisation potential of the test substance according to OECD guideline
429 (local lymph node assay), in compliance with GLP. Male CBA/Ca mice
were exposed to the test substance at concentrations of 0, 3, 10 and 30
% in acetone. Isotope (3H-methyl thymidine) incorporation was measured
in lymph nodes. The negative (vehicle alone) and positive
(hexylcinnamaldehyde at concentrations of 1, 3, and 10 % w/v in acetone)
controls were valid. The isotope incorporation was increased by less
than a threefold at all concentrations of the test substance. Under the
study conditions, the test substance was considered to be not
sensitizing to mouse skin.
Non skin sensitizer
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