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EC number: 227-876-9
CAS number: 6021-61-0
Mortality ratio and group mean bodyweight
(g) of rats
Test item was dissolved in DMSO; the test
sample was prepared immediately before dosing. A preliminary study was
carried out to establish a dosing regimen, using groups of two males and
two females at two dosage, using 10-15 ml/kg body weight. In the main
experiment, groups of five male and five female rats were dosed at
levels selected using the results of the preliminary study. The animals
were dosed by oral gavage by means of a stomach tube and the dosed
volume was 15 ml per kg body weight. The animals on both, the
preliminary and the main studies were observed for 14 days after dosing.
Surviving animals were killed after two
weeks. All animals which died during the study and those killed after
two weeks were subjected to a macroscopic postmortem examination. The
macroscopic appearance of the abnormal organs was recorded.
One female died 59 hours after dosing. No
overt symptoms of poisoning were observed. No special findings could be
LD50 > 5350 mg/kg bw (males and females)
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