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EC number: 227-876-9
CAS number: 6021-61-0
Reactions - unwashed eyes
Reactions - washed eyes
Nine rabbits (New Zealand White Rabbits)
were used in the test: six animals for unwashed eyes and three animals
whose eyes were washed after instillation. Prior to the test, the eyes
of each rabbit were examined for pre-existing casual injury.
100 mg of the test material was placed
into the conjunctival sac of the right eyes of the animals. In three
animals, the treated eye was rinsed after half a minute. The eyes were
inspected after 24, 48 and 72 hours. Reading score for ocular lesions
were made according to the recommendations of the USA Food and Drug
officials, published in 1959 (Appraisal of the Safety of Chemicals in
Foods, Drugs and Cosmetics).
The irritation score resulted to be 0,
thus, the test item was judged to be non irritant, according to the
systen of classification recommended by the ETAD Subcommittee for
The scoring system criteria used to record
the hardness of the skin reactions followed in the current test are
strictly comparable to those reported into the OECD guideline, thus it
is possible to re-evaluate the results in accordance with the CLP
Regulation (EC 1272/2008).
None of the animals showed any observable
response to treatment throughout the 72 hours observation period, thus
it can be concluded that the test item does not meet the criteria to be
classified as irritating, according to the CLP Regulation (EC 1272/2008).
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