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EC number: 205-293-0 | CAS number: 137-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Genetic toxicity in vivo for Metam Sodium in Chinese hamsters using the bone marrow chromosome analysis method.
- Author:
- European Commission
- Year:
- 2 000
- Bibliographic source:
- European Commission, European Chemicals Bureau, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Principles of method if other than guideline:
- To evaluate possible clastogenicity of Metam Sodium in Chinese hamsters using the bone marrow chromosome analysis method.
- GLP compliance:
- not specified
- Type of assay:
- other: In vivo Mammalian Bone Marrow Cytogenetic Test – Chromosomal Analysis"
Test material
- Reference substance name:
- Metam-sodium
- EC Number:
- 205-293-0
- EC Name:
- Metam-sodium
- Cas Number:
- 137-42-8
- Molecular formula:
- C2H5NS2.Na
- IUPAC Name:
- sodium (methylcarbamothioyl)sulfanide
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : Metam-sodium
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : Metam-sodium
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- hamster, Chinese
- Strain:
- other: SH (chin) Ki
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- Not specified
- Details on exposure:
- Not specified
- Duration of treatment / exposure:
- 2 days
- Frequency of treatment:
- Single
- Post exposure period:
- Not specified
Doses / concentrations
- Remarks:
- 0, 150, 300 and 600 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/group
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Cyclophosphamide
- Route of administration: Oral gavage
- Doses / concentrations: 40 mg/kg
Examinations
- Tissues and cell types examined:
- bone marrow
- Details of tissue and slide preparation:
- Details of tissue and slide preparation
The animals were sacrificed and the bone marrow of the two femora was prepared 6, 24 and48 hours after administration of the highest dose and 24 hours after treatment of the other groups. - Evaluation criteria:
- 1000 metaphase cells (100/hamster) were scored for each dose level.
- Statistics:
- Not specified.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: No mutagenic effect were observed
Applicant's summary and conclusion
- Conclusions:
- Metam Sodium (137-42-8)was tested for possible clastogenicity in Chinese hamsters using the bone marrow chromosome analysis method. The test result was considered to be negative as there is no increase in the number of aberrant metaphases.
- Executive summary:
In Vivo Genetic toxicity study of Metam Sodium was assessed for its possible clastogenic effect. For this purpose In vivo Mammalian Bone Marrow Cytogenetic Test – Chromosomal Analysis" was performed according to OECD Guideline 475. The test substance was exposed to Chinese hamsters using the bone marrow chromosome analysis method. The test substance was tested in Chinese hamsters at the concentration of 0, 150, 300 and 600 mg/kg bw. The animals were sacrificed and the bone marrow of the two femora was
prepared 6, 24 and48 hours after administration of the highest dose and 24 hours after treatment of the other groups. Single oral administration of Metam Sodium in doses of 150,
300 and 600 mg/kg bw did not lead to any increase in the number of aberrant metaphases. There were no significant differences in the types and frequency of aberrations between the dose groups and the solvent control group. Therefore Metam Sodium was considered to be non mutagenic inChinese hamsters bone marrow chromosome analysis. Hence the substance cannot be classified as Gene mutant in vitro.
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