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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute Dermal toxicity of Metam-sodium (CAS no: 137-42-8) in rabbit.
Author:
U.S. National Library of Medicine
Year:
2008
Bibliographic source:
HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2008.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity of Metam-sodium (CAS no: 137-42-8) in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Metam-sodium
EC Number:
205-293-0
EC Name:
Metam-sodium
Cas Number:
137-42-8
Molecular formula:
C2H5NS2.Na
IUPAC Name:
sodium (methylcarbamothioyl)sulfanide
Details on test material:
- IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic
Specific details on test material used for the study:
- IUPAC Name: Metam-sodium
- InChI: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Smiles: C(=S)(NC)[S-].[Na+]
- Molecular formula :C2H4NNaS2
- Molecular weight:129.1826 g/mol
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
3074 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 074 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 3074 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute dermal LD50 value was considered to be 3074 mg/kg bw, when rabbits were treated with Metam-sodium (CAS no: 137-42-8) by dermal application.
Executive summary:

Acute dermal toxicity study of Metam-sodium (CAS no: 137-42-8)was conducted in rabbits at the concentration of 3074mg/kg bw . 50% mortality was observed at 3074mg/kg bw. Therefore, LD50 value was considered to be 3074mg/kg bw, when rabbits were treated with Metam-sodium (CAS no: 137-42-8) by dermal application.