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EC number: 205-293-0 | CAS number: 137-42-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database
- Title:
- Toxicological Study of Metam-Sodium (CAS No: 137-42-8)
- Author:
- HSDB
- Year:
- 2 018
- Bibliographic source:
- U.S. National Library of Medicine National Institutes of Health, Health & Human Services; 2018
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for CAS No: 137-42-8
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset; EUROPEAN COMMISSION – European Chemicals Bureau; 18–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hazardous Substances, Part 191, Section 11, FDA, Washington 1965
- Principles of method if other than guideline:
- A patch test was conducted for test chemical Metam-sodium (CAS no: 137-42-8) on the shaved intact or scarificed skin of six New Zealand White rabbits under occlusive condition to assess its skin irritating effects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Metam-sodium
- EC Number:
- 205-293-0
- EC Name:
- Metam-sodium
- Cas Number:
- 137-42-8
- Molecular formula:
- C2H5NS2.Na
- IUPAC Name:
- sodium (methylcarbamothioyl)sulfanide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : Metam-sodium
- Common name: Sodium methyldithiocarbamate
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved intact or scarificed skin
- Vehicle:
- other: aqueous solution
- Controls:
- not specified
- Amount / concentration applied:
- 50 %, 25 %, 12.5 % and 6.25 % aqueous preparations (0.5mL)
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24, 48, 72, 96, 120, 144 and 168 hours.
- Number of animals:
- 6 (3/sex)
- Details on study design:
- SCORING SYSTEM: according to DRAIZE
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- The 50 % preparation caused erythema (reaction stage 1 and partially 2 according to DRAIZE) and edema on the intact and scarificed skin throughout the observation period.
After application of the 25 % preparation 2 of 6 animals with intact skin and 5 of 6 animals with scarificed skin showed erythema and edema which still existed 144 hours after application.
The 12.5 % preparation caused erythema in 1 animal with intact skin whereas the highest dilution of the test substance was without effect in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material Metam-sodium (CAS no: 137-42-8) was considered to be irritating to the skin of six New Zealand White rabbits.
- Executive summary:
A patch test was conducted for test chemical Metam-sodium (CAS no: 137-42-8) on six New Zealand White rabbits under occlusive condition according to Hazardous Substances, Part 191, Section 11, FDA, Washington 1965.
About 0.5ml of 50 %, 25 %, 12.5 % and 6.25 % aqueous preparations was applied the shaved intact or scarificed skin of each rabbits and skin reactions were read after 24, 48, 72, 96, 120, 144 and 168 hours.
The 50 % preparation caused erythema (reaction stage 1 and partially 2 according to DRAIZE) and edema on the intact and scarificed skin throughout the observation period. After application of the 25 % preparation 2 of 6 animals with intact skin and 5 of 6 animals with scarificed skin showed erythema and edema which still existed 144 hours after application. The 12.5 % preparation caused erythema in 1 animal with intact skin whereas the highest dilution of the test substance was without effect in all animals.
Hence under the test condition, the chemical Metam-sodium (CAS no: 137-42-8) was considered to be irritating to the skin of six New Zealand White rabbits.
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