Metam-sodium

Endpoint summary

Link to relevant study record(s)

Reference

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from European Food Safety Authority

Objective of study:

absorption

distribution

excretion

metabolism

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

In vivo Absorption, Distribution, Excretionand Metabolism study of 44-( Metam-sodium in mice and rat

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Metam-sodium
- Molecular formula (if other than submission substance): C2H4NNaS2
- Molecular weight (if other than submission substance): 129.1826 g/mole
- Substance type: Organic

Radiolabelling:

not specified

Species:

other: Mice and rat

Strain:

not specified

Sex:

not specified

Route of administration:

not specified

Vehicle:

not specified

Details on exposure:

not specified

Duration and frequency of treatment / exposure:

not specified

Remarks:

not specified

No. of animals per sex per dose / concentration:

not specified

Control animals:

not specified

Positive control reference chemical:

not specified

Details on study design:

not specified

Details on dosing and sampling:

not specified

Statistics:

not specified

Preliminary studies:

not specified

Type:

absorption

Results:

Oral absorption of metam is rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively).

Type:

distribution

Results:

Metam is uniformly distributed with slight accumulation in the thyroid in mice and rats

Type:

metabolism

Results:

The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air.

Type:

excretion

Results:

Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.

Details on absorption:

Oral absorption of metam is rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively).

Details on distribution in tissues:

Metam is uniformly distributed with slight accumulation in the thyroid in mice and rats

Details on excretion:

Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.

Metabolites identified:

yes

Remarks:

MITC, CO2, and COS. MITC, CS2

Details on metabolites:

The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion.

Conclusions:

Low bio-accumulation potential based on study results

Executive summary:

Available data pertaining to the in-vivo Absorption,Distribution, Metabolism and Excretion of the chemical 4-(Metam-sodium suggests absorbed Orally rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively) and uniformly distributed with slight accumulation in the thyroid in mice and rats. The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion. Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.Thus, there is low evidence of4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, th use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.    

Description of key information

There is low evidence of 4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, it use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.    

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Additional information

Available data pertaining to the in-vivo Absorption,Distribution, Metabolism and Excretion of the chemical 4-(Metam-sodium suggests absorbed Orally rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively) and uniformly distributed with slight accumulation in the thyroid in mice and rats. The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion. Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.Thus, there is low evidence of4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, th use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.